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CONTENTS EDITORIALS
EUROPEAN
RESPIRATORY
journal
CONTENTS
VOLUME 43 / NUMBER 2 / FEBRUARY 2014
EDITORIALS
315
Trustworthy guidelines on severe asthma thanks to the ERS and ATS
Guy G. Brusselle and Monica Kraft
319
Asthma control in the workplace
Louis-Philippe Boulet
322
Towards the next stage of novel biomarker discussion in COPD: Tekizai-Tekisho
Toru Oga, Kazuo Chin and Michiaki Mishima
325
Translational research in pulmonary hypertension: challenge and opportunity
Norbert F. Voelkel and Marc Humbert
329
Standing on shoulders
Peter J.F.M. Merkus
331
Pneumococcal serotypes and respiratory failure: soil or seed?
Mark Woodhead
334
Ambulatory management of primary spontaneous pneumothorax: the good is (not always) the enemy of
the better (evidence)
Arschang Valipour
337
Relapses of sarcoidosis: what are they and can we predict who will get them?
Robert P. Baughman and Marc A. Judson
340
Lung function, genetics and ethnicity
Peter Burney and Richard Hooper
ERS/ATS GUIDELINES
Press
release
343
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung, Sally E. Wenzel, Jan L. Brozek, Andrew Bush, Mario Castro, Peter J. Sterk, Ian M. Adcock,
Eric D. Bateman, Elisabeth H. Bel, Eugene R. Bleecker, Louis-Philippe Boulet, Christopher Brightling,
Pascal Chanez, Sven-Erik Dahlen, Ratko Djukanovic, Urs Frey, Mina Gaga, Peter Gibson, Qutayba Hamid,
Nizar N. Jajour, Thais Mauad, Ronald L. Sorkness and W. Gerald Teague
ORIGINAL ARTICLES
Occupational lung disease
374
Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory
Health Survey II
Nicole Le Moual, Anne-Elie Carsin, Valérie Siroux, Katja Radon, Dan Norback, Kjell Torén, Mario Olivieri,
Isabel Urrutia, Lucia Cazzoletti, Bénédicte Jacquemin, Geza Benke, Hans Kromhout, Maria C. Mirabelli,
Amar J. Mehta, Vivi Schlünssen, Torben Sigsgaard, Paul D. Blanc, Manolis Kogevinas, Josep M. Antó and
Jan-Paul Zock
COPD
387
Target lobe volume reduction and COPD outcome measures after endobronchial valve therapy
Arschang Valipour, Felix J.F. Herth, Otto C. Burghuber, Gerard Criner, Jean-Michel Vergnon,
Jonathan Goldin, Frank Sciurba and Armin Ernst for the VENT study group
397
Adrenomedullin refines mortality prediction by the BODE index in COPD: the “BODE-A” index
Daiana Stolz, Kostantinos Kostikas, Francesco Blasi, Wim Boersma, Branislava Milenkovic, Alicia Lacoma,
Renaud Louis, Joachim G. Aerts, Tobias Welte, Antoni Torres, Gernot G.U. Rohde, Lucas Boeck,
Janko Rakic, Andreas Scherr, Sabine Hertel, Sven Giersdorf and Michael Tamm
409
The effect of peroxisome proliferator-activated receptor- ligands on in vitro and in vivo models of COPD
Simon Lea, Jonathan Plumb, Hannah Metcalfe, Dianne Spicer, Paul Woodman, J. Craig Fox and Dave Singh
421
Differences in plasma and sputum biomarkers between COPD and COPD–asthma overlap
Hiroshi Iwamoto, Jing Gao, Jukka Koskela, Vuokko Kinnula, Hideo Kobayashi, Tarja Laitinen and
Witold Mazur
430
Plasma advanced glycation end-products and skin autofluorescence are increased in COPD
Poornima Gopal, Niki L. Reynaert, Jean L.J.M. Scheijen, Lean Engelen, Casper G. Schalkwijk,
Frits M.E. Franssen, Emiel F.M. Wouters and Erica P.A. Rutten
ORIGINAL ARTICLES (CONTINUED)
Asthma
439
Genetic heterogeneity of asthma phenotypes identified by a clustering approach
Valérie Siroux, Juan R. González, Emmanuelle Bouzigon, Ivan Curjuric, Anne Boudier, Medea Imboden,
Josep Maria Anto, Ivo Gut, Deborah Jarvis, Mark Lathrop, Ernst Reidar Omenaas, Isabelle Pin,
Mathias Wjst, Florence Demenais, Nicole Probst-Hensch, Manolis Kogevinas and Francine Kauffmann
453
Lipid mediator profiles differ between lung compartments in asthmatic and healthy humans
Nirina Larsson, Susanna L. Lundström, Rui Pinto, Gregory Rankin, Masoumeh Karimpour,
Anders Blomberg, Thomas Sandström, Jamshid Pourazar, Johan Trygg, Annelie F. Behndig,
Craig E. Wheelock and Malin L. Nording
464
Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming
growth factor-1 in airway fibroblasts in asthma
Rafael Firszt, Dave Francisco, Tony D. Church, Joseph M. Thomas, Jennifer L. Ingram and Monica Kraft
474
Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control
Junpei Saito, David Gibeon, Patricia Macedo, Andrew Menzies-Gow, Pankaj K. Bhavsar and Kian Fan Chung
Paediatric pneumology
485
Ciliary dyskinesia is an early feature of respiratory syncytial virus infection
Claire M. Smith, Hemant Kulkarni, Priya Radhakrishnan, Andrew Rutman, Michael J. Bankart,
Gwyneth Williams, Robert A. Hirst, Andrew J. Easton, Peter W. Andrew and Chris O’Callaghan
497
Membrane and capillary components of lung diffusion and pro-angiogenic cells in infants
Daniel V. Chang, Christina J. Tiller, Jeffrey A. Kisling, Jamie Case, Julie A. Mund, Laura S. Haneline,
David A. Ingram and Robert S. Tepper
Lung function
505
Grading the severity of airways obstruction: new wine in new bottles
Philip H. Quanjer, Jeffrey J. Pretto, Danny J. Brazzale and Piotr W. Boros
Sleep medicine
513
Visceral white fat remodelling contributes to intermittent hypoxia-induced atherogenesis
Laureline Poulain, Amandine Thomas, Jennifer Rieusset, Louis Casteilla, Patrick Levy, Claire Arnaud and
Maurice Dematteis
Pulmonary vascular diseases
523
Sex and haemodynamics in pulmonary arterial hypertension
Corey E. Ventetuolo, Amy Praestgaard, Harold I. Palevsky, James R. Klinger, Scott D. Halpern and
Steven M. Kawut
531
Targeting cell motility in pulmonary arterial hypertension
Roxane Paulin, Jolyane Meloche, Audrey Courboulin, Caroline Lambert, Alois Haromy, Antony Courchesne,
Pierre Bonnet, Steeve Provencher, Evangelos D. Michelakis and Sébastien Bonnet
Respiratory infections
CME article
545
Risk factors for respiratory failure in pneumococcal pneumonia: the importance of pneumococcal
serotypes
Joaquín Burgos, Manel Luján, Maria Nieves Larrosa, Dionísia Fontanals, Guadalupe Bermudo,
Ana Maria Planes, Mireia Puig, Jordi Rello, Vicenç Falcó and Albert Pahissa
Tuberculosis
Press
release
554
Costs of tuberculosis disease in the European Union: a systematic analysis and cost calculation
Roland Diel, Joris Vandeputte, Gerard de Vries, Jonathan Stillo, Maryse Wanlin and Albert Nienhaus
566
Comparing cost-effectiveness of standardised tuberculosis treatments given varying drug resistance
Stephanie Law, Andrea Benedetti, Olivia Oxlade, Kevin Schwartzman and Dick Menzies
Pleural diseases
582
Outpatient management of primary spontaneous pneumothorax: a prospective study
Massongo Massongo, Sylvie Leroy, Arnaud Scherpereel, Fabien Vaniet, Xavier Dhalluin, Bachar Chahine,
Céline Sanfiorenzo, Michaël Genin and Charles-Hugo Marquette
Bronchoscopy
591
Propofol sedation for flexible bronchoscopy: a randomised, noninferiority trial
Peter Grendelmeier, Michael Tamm, Eric Pflimlin and Daiana Stolz
Interstitial and orphan lung disease
602
Prediction of relapse after discontinuation of infliximab therapy in servere sarcoidosis
Adriane D.M. Vorselaars, Anouk Verwoerd, Coline H.M. van Moorsel, Ruth G.M. Keijsers, Ger T. Rijkers and
Jan C. Grutters
REVIEW
610
Clinimetric properties of bronchoalveolar lavage inflammatory markers in cystic fibrosis
Michael Fayon, Lisa Kent, Stephanie Bui, Lieven Dupont and Isabelle Sermet on behalf of the European
Cystic Fibrosis Society Clinical Trial Network (ECFS-CTN) Standardisation Committee
AGORA
Research letters
627
Disconnect between sputum neutrophils and other measures of airway inflammation in asthma
Joseph R. Arron, David F. Choy, Michel Laviolette, Steven G. Kelsen, Ammar Hatab, Richard Leigh,
Neil C. Thomson, Eugene R. Bleecker, Ron Olivenstein, Pedro C. Avila, Nizar N. Jarjour, Mario Castro,
Gail M. Gauvreau, James T. Good, Joel N. Kline, Adel Mansur, Irvin Mayers, Liam G. Heaney, Qutayba Hamid
and Jeffrey M. Harris
630
Impact of cigarette smoking on latent tuberculosis infection: does age matter?
Jia-Yih Feng, Shiang-Fen Huang, Wen-Ying Ting, Ming-Che Lee, Yu-Chun Chen, Yung-Yang Lin, Yu-Chin Lee
and Wei-Juin Su
632
A tale of two settings: the role of the Beijing genotype in the epidemiology of multidrug-resistant
tuberculosis
Helen R. Stagg, Ted Cohen, Mercedes C. Becerra, Laura F. Anderson and Ibrahim Abubakar
635
Helicobacter pylori seroprevalence in patients with idiopathic pulmonary fibrosis
David Bennett, Elena Bargagli, Rosa Metella Refini, Maria Stella Campagna, Luigi Gennari, Ranuccio Nuti,
Natale Figura and Paola Rottoli
638
Combined pulmonary fibrosis and emphysema syndrome associated with ABCA3 mutations
Ralph Epaud, Céline Delestrain, Malek Louha, Stéphanie Simon, Pascale Fanen and Abdellatif Tazi
641
Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy
David Montani, Barbara Girerd, Sven Günther, Florence Riant, Elisabeth Tournier-Lasserve, Laurent Magy,
Nizar Maazi, Christophe Guignabert, Laurent Savale, Olivier Sitbon, Gérald Simonneau, Florent Soubrier
and Marc Humbert
644
Enhanced detection of Legionnaires’ disease by PCR testing of induced sputum and throat swabs
Michael J. Maze, Sandy Slow, Anne-Marie Cumins, Kenjin Boon, Patricia Goulter, Roslyn G. Podmore,
Trevor P. Anderson, Kevin Barratt, Sheryl A. Young, Alan D. Pithie, Michael J. Epton, Anja M. Werno,
Stephen T. Chambers and David R. Murdoch
Correspondence
647
Asymmetric dimethylarginine and asthma
Jeremy A. Scott, Gail. M. Gauvreau and Hartmut Grasemann
648
Early-life wheeze: “the Child is father to the Man”
Ramesh J. Kurukulaaratchy, Sian Evans and S. Hasan Arshad; Vegard Hovland, Amund Riiser,
Petter Mowinckel, Kai-Håkon Carlsen and Karin C. Lødrup Carlsen
651
Can overweight/obesity and smoking have combined effects on bronchial hyperresponsiveness?
Bruno Sposato and Marco Scalese; Maria Juusela, Paula Pallasaho, Eva Rönmark, Seppo Sarna,
Anssi Sovijärvi and Bo Lundbäck
655
Lung clearance index: should we really go back to nitrogen washout?
Jørgen G. Nielsen; Sven M. Schulzke and Urs Frey
658
AUTHOR CORRECTIONS
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