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MINEWS The E-newsletter of Einstein’s M & I Department Summer 2008

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MINEWS The E-newsletter of Einstein’s M & I Department Summer 2008
MINEWS
The E-newsletter of Einstein’s M & I Department
Summer 2008
Editors: Teresa DiLorenzo, Arturo Casadevall
A Message from the Editors
Welcome to the second issue of MINEWS, the e-newsletter of the M & I Department. Here’s
what you said about the inaugural issue:
“It's great to know that so many people in our department are doing so well - it really does
spread the cheer and make this "department that's spread all over the campus" unite as one in
our achievements.”
“I think the newsletter is great!”
“Congratulations on this little thing that goes a long way in connecting us all.”
Thank you for your appreciation of our efforts! Special thanks also to those of you who have
taken the time to share your news and successes. Please send comments and suggestions to
[email protected] We look forward to hearing from you!
Departmental News from the Chair
Successful Renewal of Microbial Pathogenesis Training Grant
The Microbial Pathogenesis Training Grant (PI: Casadevall) was successfully renewed in 2008,
providing funding for three pre- and three post-doctoral trainees per year for the next five
years. This program was begun in 1996 under the leadership of Marshall Horwitz. The grant
was successfully renewed in 2001, but in 2006 we missed the payline by three points. A
revised application was submitted in 2007 and scored comfortably within the payline.
Congratulations to all the trainers, students, and postdoctoral fellows who participate in this
program. Special thanks to Susan Nuccio and the office staff who labored tirelessly and
obtained and collated all the information needed to assemble the innumerable tables required
for the application. This grant is the core of our training program in microbial pathogenesis and
its renewal is a vote of confidence in our program at a time of very tight NIH money.
Departmental Growth
Recruitment for an additional 1-2 faculty positions continues. This summer and fall will see
several applicants visit AECOM for seminars and interviews. We are pleased with the superb
quality of the prospective applicants. Please support this effort by attending seminars and
meeting with candidates when asked. We are hoping to complete the recruitment process by
the end of this calendar year.
Price Center
The Jacobs laboratory is now in the Price center. We anticipate that other laboratories will soon
be operating there as recruits from M & I and ID/Medicine occupy 5th floor space.
4th Floor Forchheimer Renovation
The renovation will proceed in three stages to minimize disturbing research activities. In the
past month, plans were finalized for renovating one third of the central block of space. The
plans were developed by a committee of 4th floor faculty including Drs. Feldmesser, Porcelli,
Goldstein, Prasad, and Casadevall in close consultation with the AECOM Engineering
Department. The initial renovation will focus on the central spaces closest to the Chanin
building. Work is scheduled to commence shortly and we are hopeful that this effort will result in
significantly improved working spaces.
Student Invited Speaker
In the academic year 2008-2009, students will be asked to invite a speaker of their choice. This
will be an opportunity for students to interact directly with an investigator from another institution.
At this time we need to get student input and volunteers to organize this effort.
Seminar and WIP Attendance
The Department considers attendance at seminars and WIP an obligation for students,
postdocs and faculty. This is an essential aspect of our educational function. It is very apparent
that some members of our Department have excellent attendance records while others seldom
participate. Please make every effort to attend seminars/WIP and note that these begin on time.
I look forward to seeing you there.
A New M & I Faculty Member
Vyacheslav (Slava) Adarichev was recruited by Einstein's Department of Medicine, Division of
Rheumatology, from the Rush University Medical Center, Chicago, IL. Dr. Adarichev has a
secondary appointment in M & I. He has expertise in genetics and pathophysiology of
autoimmune diseases such as rheumatoid arthritis and ankylosing spondylitis experimentally
induced in susceptible murine strains. His lab is in Forchheimer 713.
Attention Graduate Students!
The Sue Golding Microbial Pathogenesis Course has moved to the fall semester and will
begin this August. Marta Feldmesser and Michelle Larsen will direct this biennial course,
which is sponsored in part by the Microbial Pathogenesis Training Grant. The sessions will
feature many of the outstanding M & I faculty, as well as external speakers and journal clubs.
The 2008 M & I Retreat
The Department is indebted to Jurgen Brojatsch, faculty organizer of the 2008 M & I Retreat,
for devoting an extraordinary amount of time, effort, and heart to what was a wonderful
camaraderie-building event. Here Jurgen provides a recap of the event:
This year's M & I retreat was held at the New York Botanical Garden in the Bronx. The retreat
offered the participants a chance to become familiar with the different directions the Department
has been taking over the years. The research was represented by talks and posters from
students and postdocs whose topics ranged from tuberculosis gene clusters to
immunotherapeutic approaches in HIV/AIDS. The highlight of the scientific program was a
MINEWS--Summer 2008
2
presentation by Craig Roy, from the Microbial Pathogenesis Department at Yale University,
about trafficking of Legionella pneumophila proteins. The social part of the day included
highlights such as a scavenger hunt that led us through the depths of the Gardens and a
hilarious skit about the idiosyncrasies of our honorable faculty and some of the challenges
facing the weekly pizza-hour. This retreat was made possible due to generous financial support
from the College and the outstanding contributions by the organizing committee and our
invaluable administrative staff. Everyone who contributed to the retreat was instrumental in
making it a great success. In particular I would like to highlight the heroic efforts of: Maria
Gasparino, Maria Ortiz, Susan Nuccio, Hongliang Zhou, Scott Garforth, Gabriel Bricard,
Emilia Falkowska, Carolyn Saylor, Nareen Abboud, Stefan Muehlbauer, Koenraad Van
Doorslaer, Kartik Chandran and last, but not least, our fearless leader Arturo Casadevall.
American Society for Microbiology (ASM) Student Chapter at Einstein
Magdia De Jesus (Casadevall lab) reports that she and Teraya Donaldson (Kim lab) are
establishing an ASM student chapter at Einstein. The purpose of this organization will be to
promote student interest and further improve the quality of the microbiology program at Einstein.
The chapter will offer students a chance to:
1. Host student-invited speakers.
2. Learn how to prepare an impressive CV or Biosketch.
3. Learn how to secure a good post-doctoral position and beyond.
4. Attend seminars on alternative careers in microbiology.
5. Sponsor a research symposium, with posters or student presentations.
6. Allow students to network with faculty and students in other institutions and present
research in local branch forums as a result of alliance to the ASM Branch in New York
City.
Magdia and Teraya have drafted a brief proposal and are awaiting approval from ASM.
Following ASM approval, the student chapter will need a secretary, treasurer and public
relations officer.
Since the program's inception in 1970, the ASM Council has approved Student Chapters at
the following institutions (source: www.asm.org):
Auburn University
Saint Louis University
Ball State University
*Shenandoah Valley
*Boston Area Student Chapter
South Dakota University
Brigham Young University
Sul Ross State University
California State University - Chico
Texas A&M University
California State University, Long Beach
Texas State University - San Marcos
California State University, Northridge
Texas Tech University
California State University, Sacramento
University of California, Berkeley
Central Michigan University
University of California, Davis
Clemson University
*University of Georgia, Athens
Delta College
University of Hawaii
Duquesne University
University of Houston, Downtown
Eastern Michigan University
University of Iowa
Eastern Pennsylvania Student Chapter
University of Kansas
MINEWS--Summer 2008
3
George Mason University
University of Maine
Georgia Institute of Technology
University of Maryland
Howard University
University of Massachusetts - Amherst
Idaho State University
University of Miami
Iowa State University
University of Michigan, Flint
Mexican Society for Microbiology
University of Minnesota
Miami University (Ohio)
University of Missouri, Rolla
Michigan State University
*University of Nevada, Las Vegas
Michigan Technological University
University of Texas at Arlington
North Dakota State University
University of Washington
Ohio State University
University of Wisconsin, La Crosse
Ohio University
University of Wisconsin, Madison
Ohio-Wesleyan
University of Wisconsin, Oshkosh
Oklahoma State University
Virginia Tech University
Oregon State University
Western Michigan University
Pennsylvania State University
* Approved by Council at the 2007 General Meeting.
Ph.D. Students Meet with the Board of Overseers
On April 9, 2008, the Einstein Board of Overseers attended a dinner and reception with a select
group of eleven Einstein Ph.D. students at the Harmonie Club on East 60th Street. The M & I
students chosen by Victoria Freedman to participate in this event were Cara Chrisman
(Casadevall lab), Irene Jarchum (DiLorenzo lab), Michelle Maxson (Jacobs lab), and
Koenraad Van Doorslaer (Burk lab). The goal of the event, organized by Victoria, was to
permit the Board to meet face-to-face with the graduate students, so that they might learn firsthand of their outstanding research, as well as the challenges they face and the issues that
concern them. To this end, students and Board members were intermingled at the dinner
tables, and some of the students (including Michelle and Irene) were invited to give short afterdinner talks describing their work. Similar events will likely occur in the future.
A New Training Grant Award in Geographic Medicine and Emerging Infections
Einstein has been awarded a new training grant in Geographic Medicine and Emerging
Infections (Director Herb Tanowitz; Associate Director Kami Kim) by the National Institute of
Allergy and Infectious Diseases. This five-year grant will support both predoctoral and
postdoctoral trainees (three each per year). Trainers in M & I include Kami Kim, Arturo
Casadevall, John Chan, Kartik Chandran, Tanya Dragic, Marta Feldmesser, Bettina Fries,
Bill Jacobs, Jack Lenz, Josh Nosanchuk, Liise-anne Pirofski, and Vinayaka Prasad. The
focus of this training program will be global health, international medicine and emerging
infectious diseases. Projects that are translational, clinically relevant, and multidisciplinary will
be particularly encouraged. M & I trainees supported by this training grant include Lee
Kozakiewicz (Chan lab; B cells and TB), Tony Wang (Chandran lab; Ebola virus), and Sarah
Hochman (Kim lab in collaboration with the Goldstein and Prasad labs; interaction of HIV and
malaria).
MINEWS--Summer 2008
4
Update on Einstein’s Global Health Center
Vinayaka Prasad is the Chair of the Steering Committee of the newly formed Einstein Global
Health Center. He has submitted the following exciting update on the Center’s progress:
The Einstein Global Health Center (GHC), run by the GHC Steering Committee under the
leadership of Dr. Vinayaka R. Prasad from the Department of M & I, is off to a terrific start. In
just the few months since it started, the GHC has begun a successful ‘Global Health Club
Seminar Series’, launched a Global Health Pilot grants program, appointed a capable individual
as the GHC Program Coordinator (Ms. Andrea Provost, MPH), and generated College-wide
excitement in international health-related activities. More opportunities and new programs are
to follow in the coming year.
The major objectives of the GHC are to stimulate global health activities (research, education
and treatment) at Einstein, provide a centralized source of advice and support for new
international programs at Einstein, and bring together existing international programs including
the AIDS International Training and Research Program (AITRP; PI: V. Prasad), the Global
Infectious Diseases Training Program (PI: H. Tanowitz) and the Research Ethics Program in
South America (PI: R. Macklin), as well as to create more programs of this kind school-wide.
The GHC is currently run by a Steering Committee chaired by V. Prasad, and the other
members include Drs. Louis M. Weiss, Ruth Macklin, Sarita Shah, Meredith Hawkins, Jerry
Paccione and Paul Marantz.
India and Einstein. A top level team from the Government of India visited Einstein recently for
a full day’s meeting to review ongoing research and training programs with India as well as to
explore new opportunities for future India-Einstein cooperation. The team included the Minister
of Health, Dr. Anbumani Ramadoss, a top-notch Indian science administrator, Dr. Nirmal K.
Ganguly, and the Indian Embassy science staff. The visiting team was very impressed with the
breadth and depth of Einstein’s India programs. A large majority of the programs were those
supported by the AIDS International Training and Research Program, headed by Dr. Prasad.
The collaborative programs presented to the Indian group included projects led by several M & I
faculty on TB (Bill Jacobs), mechanisms of HIV-induced cell death (Ganjam Kalpana), HIVassociated dementia (Prasad) and fungal pathogenesis (Bettina Fries, Arturo Casadevall,
Josh Nosanchuk, David Goldman). Dr. Harris Goldstein’s presentation of the summary of the
CFAR pilot grant awarded to Dr. Ellie Schoenbaum and Nina Cooperman to develop a women’s
clinic in Mumbai for an epidemiological study of HAART was also well appreciated. The Indian
team was highly appreciative of the AITRP-CFAR joint, in-country meetings organized by
Prasad, Kalpana and Ellie Schoenbaum with support from CFAR (Harris Goldstein) held in
India over the past few years.
Beckman Equipment Room, 108 Ullmann
Tom Leyh has been working with the Beckman Instrument Company to create an equipmentresource for M & I, which is now fully operational. The equipment room (108 Ullmann, labeled
The Beckman Room) houses: 1) an Optima L-100 XP Ultracentrifuge [Ti 70 (fixed angle) and
SW 41 (swinging bucket) rotors]; 2) an Avanti JE centrifuge with nice set of rotors; 3) an Allegra
X-15R table top centrifuge; 4) a UV/Vis spectrophotometer. The keycode for the room can be
obtained from Tom ([email protected]). Please use (and respect!) this equipment. To
MINEWS--Summer 2008
5
preserve the integrity of the equipment, Tom is requesting that the rotors not leave the room for
any reason without his explicit consent. Beckman is supporting this equipment and would like
nothing more than to see it extensively used. Looking forward, Tom is hoping to establish a
program with Beckman to bring new and innovative equipment into the space for trial and
training.
News from the Students
1. Abboud, Nareen (Casadevall Lab)
Publication:
Abboud, N., and A. Casadevall. 2008. Immunogenicity of Bacillus anthracis protective antigen
domains and efficacy of elicited antibody responses depend on host genetic
background. Clin Vaccine Immunol 15:1115-1123.
2. Chrisman, Cara (Casadevall Lab)
Publication:
Zaragoza, O., C. J. Chrisman, M. V. Castelli, S. Frases, M. Cuenca-Estrella, J. L. Rodriguez
Tudela, and A. Casadevall. 2008. Capsule enlargement in Cryptococcus neoformans
confers resistance to oxidative stress suggesting a mechanism for intracellular survival.
Cell Microbiol (in press).
3. Hofmeyer, Kimberly (Zang Lab)
Publication:
Hofmeyer, K. A.*, A. Ray*, and X. Zang. 2008. B7-H3 acts through T cell costimulation and
coinhibition and beyond (invited commentary). Proc Natl Acad Sci U S A (in press).
*equal contributors
4. Jarchum, Irene (DiLorenzo Lab)
Publications:
Mukhopadhaya, A., T. Hanafusa, I. Jarchum, Y. G. Chen, Y. Iwai, D. V. Serreze, R. M.
Steinman, K. V. Tarbell, and T. P. DiLorenzo. 2008. Selective delivery of β cell antigen to
dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in
NOD mice. Proc Natl Acad Sci U S A 105:6374-6379.
Antal, Z., I. Jarchum, and T. P. DiLorenzo. 2008. HLA class I supertypes in type 1 diabetic
children in an urban children’s hospital. Ann NY Acad Sci (in press).
Presentation:
M & I Retreat 2008, “The role of IGRP- and insulin-reactive CD8 T cells during development
MINEWS--Summer 2008
6
of type 1 diabetes.” Oral presentation.
5. Sambandan, Dhinakaran (Jacobs Lab)
Publication:
Ojha, A. K., A. D. Baughn, D. Sambandan, T. Hsu, X. Trivelli, Y. Guerardel, A. Alahari, L.
Kremer, W. R. Jacobs, Jr., and G. F. Hatfull. 2008. Growth of Mycobacterium
tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Mol Microbiol 69:164-174.
6. Sango, Kaori (Goldstein Lab)
Awards and Honors:
Awarded a full scholarship to attend XVII International AIDS Conference in Mexico City, Mexico,
3-8 August 2008.
Presentation:
Will give an oral presentation at XVII International AIDS Conference in Mexico City, Mexico, 3-8
August 2008.
7. Saylor, Carolyn (Casadevall Lab)
Publication:
Alvarez, M., C. Saylor, and A. Casadevall. 2008. Antibody action after phagocytosis promotes
Cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilmlike microcolony formation. Cell Microbiol (in press).
8. Schweitzer, Andrew (Dadachova Lab)
Publication:
Rakesh, V., A. D. Schweitzer, O. Zaragoza, R. Bryan, K. Wong, A. Datta, A. Casadevall, and E.
Dadachova. 2008. Finite-element model of interaction between fungal polysaccharide
and monoclonal antibody in the capsule of Cryptococcus neoformans. J Phys Chem B
(in press).
Presentation:
Annual Meeting of HHMI Research Fellows, Chevy Chase, MD
"Rational design and physico-chemical evaluation of synthetic melanins as novel nature-inspired
radioprotectors"
Oral presentation
MINEWS--Summer 2008
7
9. Sweeney, Kari Ann (Jacobs Lab)
Publication:
Dao, D. N., K. Sweeney, T. Hsu, S. S. Gurcha, I. P. Nascimento, D. Roshevsky, G. S. Besra, J.
Chan, S. A. Porcelli, and W. R. Jacobs. 2008. Mycolic acid modification by the mmaA4
gene of M. tuberculosis modulates IL-12 production. PLoS Pathog 4:e1000081.
10. Vera, Iset (Kim Lab)
Awards and Honors:
Travel award, ASM annual meeting
Biology of Parasitism Woods Hole course
Presentation:
ASM annual meeting
News from the Postdocs
1. Antal, Zoltan (DiLorenzo Lab)
Publication:
Antal, Z., I. Jarchum, and T. P. DiLorenzo. 2008. HLA class I supertypes in type 1 diabetic
children in an urban children’s hospital. Ann NY Acad Sci (in press).
2. Baughn, Tony (Jacobs Lab)
Publications:
Ojha, A. K., A. D. Baughn, D. Sambandan, T. Hsu, X. Trivelli, Y. Guerardel, A. Alahari, L.
Kremer, W. R. Jacobs, Jr., and G. F. Hatfull. 2008. Growth of Mycobacterium
tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Mol Microbiol 69:164-174.
Arai, M., M. Sobou, C. Vilcheze, A. Baughn, H. Hashizume, P. Pruksakorn, S. Ishida, M.
Matsumoto, W. R. Jacobs, Jr., and M. Kobayashi. 2008. Halicyclamine A, a marine
spongean alkaloid as a lead for anti-tuberculosis agent. Bioorg Med Chem (in press).
3. Chaparro, Rudy (DiLorenzo Lab)
Awards and Honors:
Travel award recipient, FOCIS Trainee Satellite Symposium.
MINEWS--Summer 2008
8
Presentation:
Chaparro, R. J., Burton A. R., Serreze D. V., Vignali D. A. A., and
DiLorenzo T. P. Rapid identification of MHC class I-restricted antigens relevant to
autoimmune diabetes using retrogenic T cells.
Poster presentation, Federation of Clinical Immunology Societies
(FOCIS) meeting, Trainee Satellite Symposium, June 2008, Boston.
4. Chattopadhyay, Kausik (Nathenson Lab)
Presentation:
M & I Retreat 2008, “Structural basis of T-cell costimulation by GITR ligand.” Oral presentation.
5. Dao, Dee (Jacobs Lab)
Publication:
Dao, D. N., K. Sweeney, T. Hsu, S. S. Gurcha, I. P. Nascimento, D. Roshevsky, G. S. Besra, J.
Chan, S. A. Porcelli, and W. R. Jacobs. 2008. Mycolic acid modification by the mmaA4
gene of M. tuberculosis modulates IL-12 production. PLoS Pathog 4:e1000081.
6. Frases, Susana (Casadevall Lab)
Publications:
Albuquerque, P. C., E. S. Nakayasu, M. L. Rodrigues, S. Frases, A. Casadevall, R. M.
Zancope-Oliveira, I. C. Almeida, and J. D. Nosanchuk. 2008. Vesicular transport in
Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins
and lipids in ascomycetes. Cell Microbiol (in press).
Zaragoza, O., C. J. Chrisman, M. V. Castelli, S. Frases, M. Cuenca-Estrella, J. L. Rodriguez
Tudela, and A. Casadevall. 2008. Capsule enlargement in Cryptococcus neoformans
confers resistance to oxidative stress suggesting a mechanism for intracellular survival.
Cell Microbiol (in press).
7. Garforth, Scott (Prasad Lab)
Publication:
Garforth, S. J., M. A. Parniak, and V. R. Prasad. 2008. Utilization of a deoxynucleoside
diphosphate substrate by HIV reverse transcriptase. PLoS ONE 3:e2074.
Presentations:
Experimental Biology, San Diego (2008):
Utilization of a Deoxynucleoside Diphosphate Substrate by HIV-1 Reverse Transcriptase.
MINEWS--Summer 2008
9
Scott J. Garforth and Vinayaka R. Prasad
Poster presentation
Cold Spring Harbor, Retroviruses meeting (2008):
The effect of K65A substitution in the beta3-beta4 loop of HIV-1 reverse transcriptase on
mismatched primer extension.
Scott J. Garforth, Chisanga Lwatula, Robert Domaoal, Karen Anderson and Vinayaka R. Prasad
Poster presentation
8. Gissot, Mathieu (Kim Lab)
Publications:
Thompson, R. F., M. Reimers, B. Khulan, M. Gissot, T. A. Richmond, Q. Chen, X. Zheng, K.
Kim, and J. M. Greally. 2008. An analytical pipeline for genomic representations used for
cytosine methylation studies. Bioinformatics 24:1161-1167.
Gissot, M., L. M. Ting, T. M. Daly, L. W. Bergman, P. Sinnis, and K. Kim. 2008. High mobility
group protein HMGB2 is a critical regulator of plasmodium oocyst development. J Biol
Chem 283:17030-17038.
9. Hochman, Sarah (Kim Lab)
Awards and Honors:
New York Society for Infectious Diseases Fellow Award for Basic Science Research
10. Howell, Robertha (Dadachova Lab)
Publication:
Dadachova, E., E. Revskaya, M. A. Sesay, H. Damania, R. Boucher, R. S. Sellers, R. C.
Howell, L. Burns, G. B. Thornton, A. Natarajan, G. R. Mirick, S. J. Denardo, G. L.
Denardo, and A. Casadevall. 2008. Pre-clinical evaluation and efficacy studies of a
melanin-binding IgM antibody labeled with 188Re against experimental human metastatic
melanoma in nude mice. Cancer Biol Ther (in press).
11. Jain, Neena (Fries Lab)
Publications:
Jain, N., and B. C. Fries. 2008. Phenotypic switching of Cryptococcus neoformans and
Cryptococcus gattii. Mycopathologia (in press).
Jain, N., F. Hassan, and B. C. Fries. 2008. Phenotypic switching in fungi. Current Fungal
Infection Reports (in press).
Presentation:
MINEWS--Summer 2008
10
N. Jain, A. Guerrero, Y. Hsueh, J. Heitman, B. Fries. Genetic or epigenetic loss of ALG2, a
homolog of ALG1, locks C. neoformans in a hypervirulent state. 108th ASM general meeting, F011, June 1-5, 2008, Boston, MA, USA. Poster presentation.
12. Kriakov, Jordan (Jacobs Lab)
Publication:
Kumar, V., P. Loganathan, G. Sivaramakrishnan, J. Kriakov, A. Dusthakeer, B. Subramanyam,
J. Chan, W. R. Jacobs, Jr., and N. Paranji Rama. 2008. Characterization of temperate
phage Che12 and construction of a new tool for diagnosis of tuberculosis. Tuberculosis
(Edinb) (in press).
13. Lagal, Vanessa (Kim Lab)
Publication:
Binder, E. M., V. Lagal, and K. Kim. 2008. The prodomain of Toxoplasma gondii GPI-anchored
subtilase TgSUB1 mediates its targeting to micronemes. Traffic (in press).
14. Lazar-Molnar, Eszter (Nathenson Lab)
Publication:
Lazar-Molnar, E., Q. Yan, E. Cao, U. Ramagopal, S. G. Nathenson, and S. C. Almo. 2008.
Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PDL2. Proc Natl Acad Sci U S A (in press).
Presentation:
M & I Retreat 2008, “The PD-1 co-inhibitory pathway: from structure to function.” Poster
presentation.
15. McClelland, Erin (Casadevall Lab)
Presentation:
American Society for Microbiology Meeting, June 1-5, 2008
“A Novel Gene is Correlated with Virulence in Cryptococcus neoformans”
Poster presentation
Job!
Erin will be starting at The Commonwealth Medical College (TCMC) in Pennsylvania as an
Assistant Professor on August 18, 2008. TCMC is a newly formed medical school that will
serve all of northeastern Pennsylvania and expects to accept sixty medical students and thirty
Master of Biomedical Sciences students in 2009. The College will have campuses in Scranton,
MINEWS--Summer 2008
11
Wilkes-Barre, and Williamsport. Erin will be at the Scranton campus with lab space at
University of Scranton initially (until the TCMC buildings are completed). Please join us in
wishing her well!
16. Mukhopadhaya, Arunika (DiLorenzo Lab)
Publication:
Mukhopadhaya, A., T. Hanafusa, I. Jarchum, Y. G. Chen, Y. Iwai, D. V. Serreze, R. M.
Steinman, K. V. Tarbell, and T. P. DiLorenzo. 2008. Selective delivery of β cell antigen to
dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in
NOD mice. Proc Natl Acad Sci U S A 105:6374-6379.
Presentation:
M & I Retreat 2008, “Induction of T cell tolerance by targeting of beta cell antigens to dendritic
cells in NOD mice.” Poster presentation.
17. Nicola, Andre (Casadevall Lab)
Publication:
Nicola, A. M., A. Casadevall, and D. L. Goldman. 2008. Fungal killing by mammalian
phagocytic cells. Curr Opin Microbiol (in press).
18. Revskaya, Ekaterina (Dadachova Lab)
Publications:
Dadachova, E., E. Revskaya, M. A. Sesay, H. Damania, R. Boucher, R. S. Sellers, R. C.
Howell, L. Burns, G. B. Thornton, A. Natarajan, G. R. Mirick, S. J. Denardo, G. L.
Denardo, and A. Casadevall. 2008. Pre-clinical evaluation and efficacy studies of a
melanin-binding IgM antibody labeled with 188Re against experimental human metastatic
melanoma in nude mice. Cancer Biol Ther (in press).
Dadachova, E., J. Rivera, E. Revskaya, A. Nakouzi, S. M. Cahill, M. Blumenstein, H. Xiao, D.
Rykunov, and A. Casadevall. 2008. In vitro evaluation, biodistribution and scintigraphic
imaging in mice of radiolabeled anthrax toxins. Nucl Med Biol (in press).
Presentation:
M & I Retreat 2008, “Treatment of malignant melanoma by a combination of chemotherapy and
radioimmunotherapy.” Poster presentation.
19. Rivera, Johanna (Casadevall Lab)
Publication:
MINEWS--Summer 2008
12
Goldman, D. L., W. Zeng, J. Rivera, A. Nakouzi, and A. Casadevall. 2008. Human serum
contains a protease that protects against cytotoxic activity of Bacillus anthracis lethal
toxin in vitro. Clin Vaccine Immunol 15:970-973.
20. Sun, Jinglin (Goldstein Lab)
Publications:
Sun, J., J. H. Zheng, M. Zhao, S. Lee, and H. Goldstein. 2008. Increased in vivo activation of
microglia and astrocytes in the brains of mice transgenic for an infectious R5 human
immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin
T1 in response to stimulation by lipopolysaccharides. J Virol 82:5562-5572.
Wang, H., J. Sun, and H. Goldstein. 2008. Human immunodeficiency virus type 1 infection
increases the in vivo capacity of peripheral monocytes to cross the blood-brain barrier
into the brain and the in vivo sensitivity of the blood-brain barrier to disruption by
lipopolysaccharide. J Virol 82:7591-7600.
21. Ting, Li Min (Kim Lab)
Publication:
Gissot, M., L. M. Ting, T. M. Daly, L. W. Bergman, P. Sinnis, and K. Kim. 2008. High mobility
group protein HMGB2 is a critical regulator of plasmodium oocyst development. J Biol
Chem 283:17030-17038.
22. Varshney, Avanish Kumar (Fries lab)
Presentation:
Avanish K. Varshney, Anna Kaltsas, Michael Levi, Bettina Fries. Characterization of clinical pvl
positive methicillin sensitive and resistant Staphylococcus aureus isolates in the Bronx. 108th
ASM general meeting, June 1-5, 2008, Boston, MA, USA. Poster presentation.
News from the Technicians
1. Nakouzi, Antonio (Casadevall Lab)
Publication:
Goldman, D. L., W. Zeng, J. Rivera, A. Nakouzi, and A. Casadevall. 2008. Human serum
contains a protease that protects against cytotoxic activity of Bacillus anthracis lethal
toxin in vitro. Clin Vaccine Immunol 15:970-973.
2. Ray, Anjana (Zang Lab)
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Publication:
Hofmeyer, K. A.*, A. Ray*, and X. Zang. 2008. B7-H3 acts through T cell costimulation and
coinhibition and beyond (invited commentary). Proc Natl Acad Sci U S A (in press).
*equal contributors
3. Sandesara, Rohini (Chandran Lab)
Presentation:
Sandesara, R.G. and Chandran, K. 2008. Characterization of cell entry-related proteolytic
cleavage intermediates of the Ebola virus glycoprotein. 27th Annual Meeting of the American
Society for Virology (ASV), July 12-16, Ithaca, New York. Oral presentation.
4. Xu, Jiayong (Chan Lab)
Publication:
Maglione, P. J., J. Xu, A. Casadevall, and J. Chan. 2008. Fcγ receptors regulate immune
activation and susceptibility during Mycobacterium tuberculosis infection. J Immunol
180:3329-3338.
5. Zheng, Jian Hua (Jenny) (Goldstein Lab)
Publication:
Sun, J., J. H. Zheng, M. Zhao, S. Lee, and H. Goldstein. 2008. Increased in vivo activation of
microglia and astrocytes in the brains of mice transgenic for an infectious R5 human
immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin
T1 in response to stimulation by lipopolysaccharides. J Virol 82:5562-5572.
News from the Instructors
1. Bryan, Ruth (Dadachova Lab)
Publications:
Bryan, R. A., X. Huang, A. Morgenstern, F. Bruchertseifer, A. Casadevall, and E. Dadachova.
2008. Radiofungicidal effects of external gamma radiation and antibody-targeted beta
and alpha radiation on Cryptococcus neoformans. Antimicrob Agents Chemother
52:2232-2235.
Rakesh, V., A. D. Schweitzer, O. Zaragoza, R. Bryan, K. Wong, A. Datta, A. Casadevall, and E.
Dadachova. 2008. Finite-element model of interaction between fungal polysaccharide
and monoclonal antibody in the capsule of Cryptococcus neoformans. J Phys Chem B
(in press).
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Presentation:
American Society for Microbiology 108th General Meeting, Boston, MA
"C. neoformans from mice treated with radioactive antibodies to the polysaccharide capsule
retains sensitivity to radioactivity"
Poster presentation
2. Hassani, Morad (Jacobs Lab)
Presentation:
7th International Conference on the Pathogenesis of Mycobacterial Infections (Sweden)
“Comparison of the transcriptional responses of Mycobacterium tuberculosis and
Mycobacterium bovis to nutrient starvation”
Morad Hassani and William R. Jacobs, Jr.
Poster presentation
3. Hsu, Tsungda (Jacobs Lab)
Publications:
Dao, D. N., K. Sweeney, T. Hsu, S. S. Gurcha, I. P. Nascimento, D. Roshevsky, G. S. Besra, J.
Chan, S. A. Porcelli, and W. R. Jacobs. 2008. Mycolic acid modification by the mmaA4
gene of M. tuberculosis modulates IL-12 production. PLoS Pathog 4:e1000081.
Ojha, A. K., A. D. Baughn, D. Sambandan, T. Hsu, X. Trivelli, Y. Guerardel, A. Alahari, L.
Kremer, W. R. Jacobs, Jr., and G. F. Hatfull. 2008. Growth of Mycobacterium
tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Mol Microbiol 69:164-174.
4. Vilcheze, Catherine (Jacobs Lab)
Publication:
Arai, M., M. Sobou, C. Vilcheze, A. Baughn, H. Hashizume, P. Pruksakorn, S. Ishida, M.
Matsumoto, W. R. Jacobs, Jr., and M. Kobayashi. 2008. Halicyclamine A, a marine
spongean alkaloid as a lead for anti-tuberculosis agent. Bioorg Med Chem (in press).
News from the Faculty
1. Adarichev, Vyacheslav
Awards and Honors:
NIH/NIAMS R01 Research Grant, "Genetic analysis of murine spondyloarthropathy"
NIH/NIAMS R03 Research Grant, "Effects of sex-specific loci in murine arthritis"
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Publications:
Glant, T. T., S. Szanto, A. Vegvari, Z. Szabo, K. Kis-Toth, K. Mikecz, and V. A. Adarichev.
2008. Two loci on Chromosome 15 control experimentally induced arthritis through the
differential regulation of IL-6 and lymphocyte proliferation. J Immunol 181:1307-1314.
Adarichev, V. A., A. Vegvari, Z. Szabo, K. Kis-Toth, K. Mikecz, and T. T. Glant. 2008. Congenic
strains displaying similar clinical phenotype of arthritis represent different immunologic
models of inflammation. Genes Immun (in press).
2. Casadevall, Arturo
Publications:
Nicola, A. M., A. Casadevall, and D. L. Goldman. 2008. Fungal killing by mammalian
phagocytic cells. Curr Opin Microbiol (in press).
Rakesh, V., A. D. Schweitzer, O. Zaragoza, R. Bryan, K. Wong, A. Datta, A. Casadevall, and E.
Dadachova. 2008. Finite-element model of interaction between fungal polysaccharide
and monoclonal antibody in the capsule of Cryptococcus neoformans. J Phys Chem B
(in press).
Bryan, R. A., X. Huang, A. Morgenstern, F. Bruchertseifer, A. Casadevall, and E. Dadachova.
2008. Radiofungicidal effects of external gamma radiation and antibody-targeted beta
and alpha radiation on Cryptococcus neoformans. Antimicrob Agents Chemother
52:2232-2235.
Dadachova, E., E. Revskaya, M. A. Sesay, H. Damania, R. Boucher, R. S. Sellers, R. C.
Howell, L. Burns, G. B. Thornton, A. Natarajan, G. R. Mirick, S. J. Denardo, G. L.
Denardo, and A. Casadevall. 2008. Pre-clinical evaluation and efficacy studies of a
melanin-binding IgM antibody labeled with 188Re against experimental human metastatic
melanoma in nude mice. Cancer Biol Ther (in press).
Goldman, D. L., and A. Casadevall. 2008. Anthrax-associated shock. Front Biosci 13:40094014.
Vicencio, A. G., S. Narain, Z. Du, W. Y. Zeng, J. Ritch, A. Casadevall, and D. L. Goldman.
2008. Pulmonary cryptococcosis induces chitinase in the rat. Respir Res 9:40.
Abboud, N., and A. Casadevall. 2008. Immunogenicity of Bacillus anthracis protective antigen
domains and efficacy of elicited antibody responses depend on host genetic
background. Clin Vaccine Immunol 15:1115-1123.
Goldman, D. L., W. Zeng, J. Rivera, A. Nakouzi, and A. Casadevall. 2008. Human serum
contains a protease that protects against cytotoxic activity of Bacillus anthracis lethal
toxin in vitro. Clin Vaccine Immunol 15:970-973.
Albuquerque, P. C., E. S. Nakayasu, M. L. Rodrigues, S. Frases, A. Casadevall, R. M.
Zancope-Oliveira, I. C. Almeida, and J. D. Nosanchuk. 2008. Vesicular transport in
Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins
and lipids in ascomycetes. Cell Microbiol (in press).
Alvarez, M., C. Saylor, and A. Casadevall. 2008. Antibody action after phagocytosis promotes
Cryptococcus neoformans and Cryptococcus gattii macrophage exocytosis with biofilmlike microcolony formation. Cell Microbiol (in press).
Zaragoza, O., C. J. Chrisman, M. V. Castelli, S. Frases, M. Cuenca-Estrella, J. L. Rodriguez
Tudela, and A. Casadevall. 2008. Capsule enlargement in Cryptococcus neoformans
confers resistance to oxidative stress suggesting a mechanism for intracellular survival.
Cell Microbiol (in press).
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3. Chan, John
Awards and Honors:
Invited to become a member of the NIH Host Interactions with Bacterial Pathogens (HIBP) study
section
Publications:
Maglione, P. J., J. Xu, A. Casadevall, and J. Chan. 2008. Fcγ receptors regulate immune
activation and susceptibility during Mycobacterium tuberculosis infection. J Immunol
180:3329-3338.
Chakravarty, S. D., G. Zhu, M. C. Tsai, V. P. Mohan, S. Marino, D. E. Kirschner, L. Huang, J.
Flynn, and J. Chan. 2008. Tumor necrosis factor blockade in chronic murine
tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the
lungs. Infect Immun 76:916-926.
4. Dadachova, Kate
Awards and Honors:
Awarded a two year Mary Kay Ash Foundation grant to investigate "Targeting viral antigens with
radiolabeled antibodies as a novel approach to treatment of cervical cancer" in collaboration
with A. Casadevall and M. Einstein.
Received the Society for Nuclear Medicine's Young Professionals' Committee Award which
recognizes the contributions of significant studies to the fields of nuclear medicine and
molecular imaging by young researchers.
Publications:
Bryan, R. A., X. Huang, A. Morgenstern, F. Bruchertseifer, A. Casadevall, and E. Dadachova.
2008. Radiofungicidal effects of external gamma radiation and antibody-targeted beta
and alpha radiation on Cryptococcus neoformans. Antimicrob Agents Chemother
52:2232-2235.
Dadachova, E., E. Revskaya, M. A. Sesay, H. Damania, R. Boucher, R. S. Sellers, R. C.
Howell, L. Burns, G. B. Thornton, A. Natarajan, G. R. Mirick, S. J. Denardo, G. L.
Denardo, and A. Casadevall. 2008. Pre-clinical evaluation and efficacy studies of a
melanin-binding IgM antibody labeled with 188Re against experimental human metastatic
melanoma in nude mice. Cancer Biol Ther (in press).
Rakesh, V., A. D. Schweitzer, O. Zaragoza, R. Bryan, K. Wong, A. Datta, A. Casadevall, and E.
Dadachova. 2008. Finite-element model of interaction between fungal polysaccharide
and monoclonal antibody in the capsule of Cryptococcus neoformans. J Phys Chem B
(in press).
Dadachova, E., J. Rivera, E. Revskaya, A. Nakouzi, S. M. Cahill, M. Blumenstein, H. Xiao, D.
Rykunov, and A. Casadevall. 2008. In vitro evaluation, biodistribution and scintigraphic
imaging in mice of radiolabeled anthrax toxins. Nucl Med Biol (in press).
Dadachova, E. 2008. Radioimmunotherapy of infection with 213Bi-labeled antibodies. Current
Radiopharm (in press).
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Presentations:
American Society for Microbiology 108th General Meeting, Boston, MA
"Ionizing radiation, radiosynthesis and melanized fungi"
Oral presentation
TechConnect Summit, Boston, MA
"Melanin-based nanoshells for protection against electromagnetic radiation and for energy
conversion"
Oral presentation
55th Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA
"Viral antigens as novel targets for radioimmunotherapy of viral cancers”
Oral presentation
55th Annual Meeting of the Society of Nuclear Medicine, New Orleans, LA
"Pre-clinical development of a 188Re-labeled melanin-binding antibody for Phase I clinical trial in
patients with metastatic melanoma"
Poster presentation
Invited speaker: "Radioimmunotherapy for infection and metastatic melanoma," Nuclear
Medicine Grand Rounds, Long Island Jewish Medical Center, New Hyde Park, NY.
5. DiLorenzo, Teresa
Publications:
Mukhopadhaya, A., T. Hanafusa, I. Jarchum, Y. G. Chen, Y. Iwai, D. V. Serreze, R. M.
Steinman, K. V. Tarbell, and T. P. DiLorenzo. 2008. Selective delivery of β cell antigen
to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in
NOD mice. Proc Natl Acad Sci U S A 105:6374-6379.
Antal, Z., I. Jarchum, and T. P. DiLorenzo. 2008. HLA class I supertypes in type 1 diabetic
children in an urban children’s hospital. Ann NY Acad Sci (in press).
Presentation:
Invited speaker: “CD8 T Cells as Therapeutic Targets in Type 1 Diabetes,” Department of
Biology Spring Graduate Seminar Series, Hofstra University, Hempstead, NY, 4/11/08
6. Goldstein, Harris
Awards and Honors:
The Einstein-Montefiore Center for AIDS Research (CFAR), directed by Harris, was recently
awarded a five-year renewal grant from the NIH exceeding $8.5 million. Read the full story at
http://www.aecom.yu.edu/home/news.asp?id=203
MINEWS--Summer 2008
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Publications:
Sun, J., J. H. Zheng, M. Zhao, S. Lee, and H. Goldstein. 2008. Increased in vivo activation of
microglia and astrocytes in the brains of mice transgenic for an infectious R5 human
immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin
T1 in response to stimulation by lipopolysaccharides. J Virol 82:5562-5572.
Wang, H., J. Sun, and H. Goldstein. 2008. Human immunodeficiency virus type 1 infection
increases the in vivo capacity of peripheral monocytes to cross the blood-brain barrier
into the brain and the in vivo sensitivity of the blood-brain barrier to disruption by
lipopolysaccharide. J Virol 82:7591-7600.
7. Jacobs, Bill
Publications:
Ojha, A. K., A. D. Baughn, D. Sambandan, T. Hsu, X. Trivelli, Y. Guerardel, A. Alahari, L.
Kremer, W. R. Jacobs, Jr., and G. F. Hatfull. 2008. Growth of Mycobacterium
tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Mol Microbiol 69:164-174.
Dao, D. N., K. Sweeney, T. Hsu, S. S. Gurcha, I. P. Nascimento, D. Roshevsky, G. S. Besra, J.
Chan, S. A. Porcelli, and W. R. Jacobs. 2008. Mycolic acid modification by the mmaA4
gene of M. tuberculosis modulates IL-12 production. PLoS Pathog 4:e1000081.
Mohamedmohaideen, N. N., S. K. Palaninathan, P. M. Morin, B. J. Williams, M. Braunstein, S.
E. Tichy, J. Locker, D. H. Russell, W. R. Jacobs, Jr., and J. C. Sacchettini. 2008.
Structure and function of the virulence-associated high-temperature requirement A of
Mycobacterium tuberculosis. Biochemistry 47:6092-6102.
Mishra, A. K., L. J. Alderwick, D. Rittmann, C. Wang, A. Bhatt, W. R. Jacobs, Jr., K. Takayama,
L. Eggeling, and G. S. Besra. 2008. Identification of a novel alpha(1-->6)
mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a
conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient
mutant. Mol Microbiol 68:1595-1613.
Kumar, V., P. Loganathan, G. Sivaramakrishnan, J. Kriakov, A. Dusthakeer, B. Subramanyam,
J. Chan, W. R. Jacobs, Jr., and N. Paranji Rama. 2008. Characterization of temperate
phage Che12 and construction of a new tool for diagnosis of tuberculosis. Tuberculosis
(Edinb) (in press).
Arai, M., M. Sobou, C. Vilcheze, A. Baughn, H. Hashizume, P. Pruksakorn, S. Ishida, M.
Matsumoto, W. R. Jacobs, Jr., and M. Kobayashi. 2008. Halicyclamine A, a marine
spongean alkaloid as a lead for anti-tuberculosis agent. Bioorg Med Chem (in press).
8. Kim, Kami
Publications:
Thompson, R. F., M. Reimers, B. Khulan, M. Gissot, T. A. Richmond, Q. Chen, X. Zheng, K.
Kim, and J. M. Greally. 2008. An analytical pipeline for genomic representations used
for cytosine methylation studies. Bioinformatics 24:1161-1167.
Gissot, M., L. M. Ting, T. M. Daly, L. W. Bergman, P. Sinnis, and K. Kim. 2008. High mobility
group protein HMGB2 is a critical regulator of plasmodium oocyst development. J Biol
Chem 283:17030-17038.
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Binder, E. M., V. Lagal, and K. Kim. 2008. The prodomain of Toxoplasma gondii GPI-anchored
subtilase TgSUB1 mediates its targeting to micronemes. Traffic (in press).
9. Nathenson, Stan
Awards and Honors:
A star-studded immunology symposium in honor of Stan’s achievements and service to Einstein
was held on June 18, 2008 in Robbins Auditorium. Read the details and view photos of the
event at
http://www.aecom.yu.edu/home/fullstory.asp?id=207
Publication:
Lazar-Molnar, E., Q. Yan, E. Cao, U. Ramagopal, S. G. Nathenson, and S. C. Almo. 2008.
Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PDL2. Proc Natl Acad Sci U S A (in press).
10. Zang, Xingxing
Awards and Honors:
Nominee of the Einstein Cancer Center for consideration by the V Foundation for Cancer
Research for a V Scholar Award.
Publications:
Hofmeyer, K. A.*, A. Ray*, and X. Zang. 2008. B7-H3 acts through T cell costimulation and
coinhibition and beyond (invited commentary). Proc Natl Acad Sci U S A (in press).
*equal contributors
Thompson, R. H.*, X. Zang*, C. M. Lohse, B. C. Leibovich, S. F. Slovin, V. E. Reuter, J. C.
Cheville, M. L. Blute, P. Russo, E. D. Kwon*, and J. P. Allison*. 2008. Serum soluble
B7x is elevated in renal cell carcinoma patients and is associated with advanced stage.
Cancer Res (in press). *equal contributors
Presentations:
Einstein/MMC CFAR Annual Retreat, “HIV: new pathways for T cell costimulation and
coinhibition,” April 2008. Oral presentation.
Albert Einstein Cancer Center (AECC) Advances Meeting, "The B7 family and cancer therapy: T
cell costimulation and coinhibition," May 2008. Oral presentation.
Other:
Appointed a faculty member of the Cancer Center and of the Diabetes Research and Training
Center.
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Fly UP