RICHARD N. KITSIS, M.D. Positions: Research interests:
RICHARD N. KITSIS, M.D. Positions: Professor, Departments of Medicine and of Cell Biology Director, Wilf Family Cardiovascular Research Institute The Dr. Gerald and Myra Dorros Chair in Cardiovascular Disease, Albert Einstein College of Medicine Research interests: Our lab is interested in fundamental mechanisms of cell death and the roles of cell death in human disease. The two major foci of the lab are: (a) to create a road map that mechanistically connects apoptosis and necrosis in hopes of creating a unified model of cell death; and (b) to develop a small molecule drug that reduces the size of myocardial infarctions. Our connections with stem cell biology are twofold: (a) we are funded to test the ability of cardioprotective small-molecules that we have already identified in preserving the viability of human iPS cell–derived cardiac myocytes administered to the myocardium; and (b) we are interested in shared mediators (e.g., caspases) and mechanistic connections between cell death and differentiation. Current grant funding: 5R01HL060665-14 (Kitsis) 08/01/1998–03/31/2014 Cardiac myocyte apoptosis: Mechanism and significance 5U01HL099776-04 (Kitsis) Ancillary Project A 07/01/2012–06/30/2014 Mechanism-guided chemical biology approach to iPSC-derived cardiomyocyte death 1R03DA031671-02 (Kitsis) 01/01/2011–12/31/2012 High-throughput screen for small molecules that modulate myocardial damage 1R01CA170911-01 (Kitsis/Libutti, co-PIs) 09/01/2012–08/31/2016 Deciphering the tissue specificity of MEN1 related tumorigenesis NIH 1R01HL111770-01A1 (Zhou, Kitsis) 08/03/2012–06/30/2016 Molecular and cellular mechanisms of calcific aortic stenosis Department of Defense (James, Kitsis/Pollard, mentors) 02/01/2011–01/31/2014 Breast Cancer Research Program Postdoctoral Fellowship, BC101008 Mechanistic role of necrosis—not apoptosis—in breast cancer Five recent publications: 1. Wencker D, Chandra M, Nguyen KT, Miao W, Garantziotis S, Factor SM, Shirani J, Armstrong RC, Kitsis RN. A mechanistic role for cardiac myocyte apoptosis in heart failure. J. Clin. Invest. 2003, 111:1497–504. 2. Nam Y-J, Mani K, Ashton AW, Peng C-F, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Molecular Cell 2004, 15:901–12. 3. Foo RS-Y, Nam Y-J, Ostreicher MJ, Metzl MD, Whelan RS, Peng C-F, Ashton AW, Fu W, Mani K, Chin S-F, Provenzano E, Ellis I, Figg N, Pinder S, Bennett MR, Caldas C, Kitsis RN. Regulation of p53 tetramerization and nuclear export by ARC. Proc. Natl. Acad. Sci. (USA) 2007, 104:20826– 31. 4. Whelan, RS, Konstantinidis K, Wei A-C, Chun Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW II, O’Rourke B, Kitsis RN. Bax regulates primary necrosis through mitochondrial dynamics. Proc. Natl. Acad. Sci. (USA) 2012, 109:6566–71. 5. Gavrilov S, Nuehrenberg T, Ashton AW, Peng C-F, Moore JC, Konstantinidis K, Mummery CL, Kitsis RN. Tbx6 regulates cardiac myocyte versus neuronal cell fate in multipotent P19CL6 cells. Differentiation. In press.