RICHARD N. KITSIS, M.D. Positions: Research interests:

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RICHARD N. KITSIS, M.D. Positions: Research interests:
Professor, Departments of Medicine and of Cell Biology
Director, Wilf Family Cardiovascular Research Institute
The Dr. Gerald and Myra Dorros Chair in Cardiovascular Disease, Albert Einstein College of Medicine
Research interests:
Our lab is interested in fundamental mechanisms of cell death and the roles of cell death in human
disease. The two major foci of the lab are: (a) to create a road map that mechanistically connects apoptosis and necrosis in hopes of creating a unified model of cell death; and (b) to develop a small molecule
drug that reduces the size of myocardial infarctions. Our connections with stem cell biology are twofold:
(a) we are funded to test the ability of cardioprotective small-molecules that we have already identified
in preserving the viability of human iPS cell–derived cardiac myocytes administered to the myocardium;
and (b) we are interested in shared mediators (e.g., caspases) and mechanistic connections between cell
death and differentiation.
Current grant funding:
5R01HL060665-14 (Kitsis)
Cardiac myocyte apoptosis: Mechanism and significance
5U01HL099776-04 (Kitsis)
Ancillary Project A
Mechanism-guided chemical biology approach to
iPSC-derived cardiomyocyte death
1R03DA031671-02 (Kitsis)
High-throughput screen for small molecules that modulate
myocardial damage
1R01CA170911-01 (Kitsis/Libutti, co-PIs) 09/01/2012–08/31/2016
Deciphering the tissue specificity of MEN1 related
NIH 1R01HL111770-01A1 (Zhou, Kitsis)
Molecular and cellular mechanisms of calcific aortic stenosis
Department of Defense
(James, Kitsis/Pollard, mentors)
Breast Cancer Research Program
Postdoctoral Fellowship, BC101008
Mechanistic role of necrosis—not apoptosis—in breast cancer
Five recent publications:
1. Wencker D, Chandra M, Nguyen KT, Miao W, Garantziotis S, Factor SM, Shirani J, Armstrong RC,
Kitsis RN. A mechanistic role for cardiac myocyte apoptosis in heart failure. J. Clin. Invest. 2003,
2. Nam Y-J, Mani K, Ashton AW, Peng C-F, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis
RN. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic
death-fold interactions. Molecular Cell 2004, 15:901–12.
3. Foo RS-Y, Nam Y-J, Ostreicher MJ, Metzl MD, Whelan RS, Peng C-F, Ashton AW, Fu W, Mani K,
Chin S-F, Provenzano E, Ellis I, Figg N, Pinder S, Bennett MR, Caldas C, Kitsis RN. Regulation of
p53 tetramerization and nuclear export by ARC. Proc. Natl. Acad. Sci. (USA) 2007, 104:20826–
4. Whelan, RS, Konstantinidis K, Wei A-C, Chun Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T,
Thompson CB, Crow MT, Gavathiotis E, Dorn GW II, O’Rourke B, Kitsis RN. Bax regulates primary
necrosis through mitochondrial dynamics. Proc. Natl. Acad. Sci. (USA) 2012, 109:6566–71.
5. Gavrilov S, Nuehrenberg T, Ashton AW, Peng C-F, Moore JC, Konstantinidis K, Mummery CL,
Kitsis RN. Tbx6 regulates cardiac myocyte versus neuronal cell fate in multipotent P19CL6 cells.
Differentiation. In press.
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