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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – BIOTECHNOLOGY
THIRD SEMESTER – NOVEMBER 2014
BT 3955 - MOLECULAR PATHOLOGY
Date : 12/11/2014
Time : 09:00-12:00
Dept. No.
Max. : 100 Marks
PART – A
Answer all the questions:
(20 marks)
I Choose the correct answer:
(5 x 1 = 5)
1. A telomere is a
a) repeating DNA sequence
c) rare DNA sequence
b) mutated DNA sequence
d) pseudo DNA sequence
2. Study of changes in gene expression
a) epigenetics
b) molecular science
c) pathology
d) sequencing
3. The process whereby bacteria enter the host cell’s tissues and spread in the body is called________.
a) toxigenety
b) evasion
c) invasion
d) attachment
4. ___________ is caused by inheritance of an abnormally expanded trinucleotide repeat (CAG) affects
the midbrain and basal ganglia.
a) Alzheimer’s disease
b) Huntington’s disease
c) Parkinson’s disease
d) Creutzfeldt-Jakob disease
5. _________ is a small molecule inhibitor synthesized in lab.
a) Iressa
b) Ertibux
c) Panitimumab
d) Celvapan
II State whether the following are true or false; if false, give reason
6. FRTA stands for free radical theory of apotopsis.
7. Epigenetics is the study of inherited changes. .
8. Genomic imprinting plays a major role in embryogenesis.
(5 x 1= 5)
.
9. Liver inflammation is the hallmark of alcoholic hepatitis.
10. YAP1 is a potent oncogene, which is amplified in various human cancers.
III Complete the following:
(5 x 1 = 5)
11. ___________is the process by which cell becomes old and dies.
12. DIGE stands for____________.
13. PAMP stands for ________________.
14. A _________ disease is a structure that permits a neuron to pass an electrical or chemical signal to
another cell.
15. ________is a humanized antibody.
IV Answer the following, each within 50 words only
(5 x 1 = 5)
16. Define mutation.
17. What are histones?
18. Why are telomeres important?
19. Expand the following a) ASVD. b) NFkB.
20. What are the two key pharmacological concepts?
PART – B
Answer the following questions, each in about 500 words only.
Draw diagrams wherever necessary.
(5×8 = 40 marks)
21 (a) Differentiate apoptosis from necrosis.
OR
(b) Comment on reactive oxygen species.
22 (a) Discuss the role of mitochondria in aging.
OR
(b) What are biomarkers of disease? Describe briefly about protein biomarkers.
23 (a) What are pattern recognition receptors? Enumerate its types and discuss the development disorders
caused by them.
.
OR
(b) Write about the molecular basis for some of the bacterial diseases.
24 (a) Give a short note on neurodegeneration.
OR
(b) Explain the mechanism involved in development of liver.
25 (a) What is the aim and advantages of pharmacogenetic studies?
OR
(b) Describe the process involved in discovery and development of drugs.
PART – C
Answer any two of the following questions, each in about 1500 words;
Draw diagrams wherever necessary.
(2×20 = 40 marks)
26. Explain the causes and mechanism involved in necrosis.
27. Give an account on teratogens, its mode of action and diseases caused by them.
28. Write briefly on (i) genetic imprinting in the development of diseases.
(ii) Mechanisms involved in atherosclerosis.
29. Explain, how the pharmacogenomic testing is now used to help and guide treatment for people with
different diseases.
**********
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