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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION – BIOTECHNOLOGY
THIRD SEMESTER – NOVEMBER 2014
BT 3824 - NANOTECHNOLOGY & MEDICAL BIOTECHNOLOGY
Date : 05/11/2014
Time : 09:00-12:00
Dept. No.
Answer all the questions:
Max. : 100 Marks
PART – A
(20 marks)
I. Choose the correct answer:
(5×1 = 5)
1) Nanoshells used for targeted killing of cancer cells is composed of which of the following?
a) Si & Au
b) Si & Ag
c) Ag & Au
d) Ga & N
2) Which of the following technique is used to synthesize carbon nanotubes?
a) Photolithography
b) Dip pen lithography
c) Plasma arcing
d) Sol gel synthesis
3) What is the inheritance pattern of Huntington’s disease?
a) Autosomal dominant
c) X- linked dominant
b) Autosomal recessive
d) X- linked recessive
4) Which is the most abundant plasma protein found in human fetus?
a) hCG
b) PAPP-A
5) BCR gene is located in chromosome number
a) 22
b) 20
c) Alpha Fetoprotein
d) Inhibin A
c)
d) 19
18
II. State whether the following are True or False, if false give reason
(5×1= 5)
6) Quantum dots are not suitable for making solar energy panels.
7) Gliadin is a used a drug carrier molecule.
8) STRs are used for DNA Fingerprinting.
9) 35% of monochorionic twins has TTT syndrome.
10) FACS can be used for sorting cancer cells.
III. Complete the following:
11) Microclusters are made of ___________________ atoms.
12) ___________________ can mimic oxygen carrying RBCs.
13) Hemophilia A is due to the lack of clotting factor ___________ .
14) Edward syndrome is due to the trisomy of ____________ chromosome
15) Mutation in _________ gene cause Li – Fraumeni syndrome.
(5×1 = 5)
IV. Answer the following questions, each within 50 words only
(5×1 = 5)
16) What is fermi level?
17) Mention one soceital implication of nanotechnology research.
18) Define genetic counseling.
19) What is FCMB?
20) What is Philadelphia chromosome?
PART – B
Answer the following questions, each in about 500 words; Draw diagrams wherever necessary:
(5×8 = 40)
21) (a) Write an account on the different types of fullerenes and their properties.
OR
( b) Outline the steps in electron beam lithography.
22) (a) Explain the role of DNA nanowires and peptide nanowires.
OR
(b) Mention the advantages of nanomaterials in reducing energy consumption.
23) (a) Give an account on cystic fibrosis.
b) Write briefly on gene therapy.
OR
24 a) Comment on the following: Fetal blood sampling, amniocentesis and CVS.
OR
b) What are the characteristics of embryonic stem cells?
25) a) Explain FACS with diagram.
OR
b) What are the mechanisms by which proto-oncogene can be converted to oncogene?
PART – C
Answer any two of the following questions, each in about 1500 words; Draw diagrams wherever
necessary:
(2×20 = 40)
26) Describe about the principle and instrumentation of atomic force and scanning tunnelling
microscopes.
27) Elaborate on the various types of nanodevices and nanoprotein mediated drug delivery.
28) Describe Type 2 diabetes, its complications, treatment and various stages of the disease.
29) Describe p53 tumour suppressor gene and its function.
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