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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION - BIO TECHNOLOGY
THIRD SEMESTER – NOVEMBER 2013
BT 3824 - NANOTECHNOLOGY & MEDICAL BIOTECHNOLOGY
Date : 09/11/2013
Time : 9:00 - 12:00
Dept. No.
Max. : 100 Marks
PART – A
Answer all the questions
I. Choose the correct answer:
(20 marks)
(5×1 = 5)
1) Who coined the term Nanotechnology?
a) Drexler
b) Taniguchi c) Buckminister
d) Feynman
2) Which of the following technique is used to prepare protein nanoarrays?
a) Photolithography
b) Dip pen lithography
c) Plasma arcing
d) Sol gel synthesis
3) Number of exons in a DMD gene is
a) 29
b) 59
c) 79
d) 89
4) What is the chance of inheriting an autosomal recessive disorder?
a) 10%
b) 15%
c) 12 %
d) 25 %
5) Sir Alec Jeffrey is associated with
a) Sequencing b) PCR
c) DNA Fingerprinting d) Apoptosis
II. State whether the following are True or False, if false give reason
(5×1= 5)
6) Quantum dots are insulators.
7) Gelatin is a highly reactive protein.
8) India is the hub of Type 2 diabetes in the world.
9) Embryonic Stem Cells are used for disease treatment.
10) Metaphase chromosomes are used for in situ hybridization.
III. Complete the following:
11) The maximum energy possessed by an electron is _____________.
12) The radiation sensitive polymer used for coating the substrate is _________.
13) Schizophrenia is an example of ___________ disease.
14) VNTR stands for ____________.
15) Most of the p53 gene mutations occur in the _______ region.
(5×1 = 5)
IV. Answer the following questions, each within 50 words only
(5×1 = 5)
16) What is a tunelling current?
17) State an application for protein nanoparticle.
18) Define gene therapy.
19) What is the purpose of prenatal diagnosis?
20) Distinguish between proto-oncogene and an oncogene. Cite one example each.
PART – B
(5×8 = 40 marks)
Answer the following questions, each within 500 words; Draw diagrams wherever necessary.
21) (a) Outline the principle and modes of operation of atomic force microscopy.
OR
( b) Outline the steps in chemical vapour deposition.
22) (a) Explain protein nanoarray synthesis.
OR
(b) Discuss the role of nanotechnology in targeting, drug delivery, imaging and toxicity issues.
23) ( a) Give an account of familial hypercholesterolemia.
OR
(b) Discuss cystic fibrosis disease.
24) (a) What is Prenatal Diagnosis (PND)? When do you have to do cytogenetical PND?
OR
(b) Explain how repetitive DNA is used as a tool in forensic sciences?
25) (a) Distinguish between BRCA1 and BRCA2.
OR
(b) Give an account of in situ hybridization
PART – C
(2×20 = 40 marks)
Answer any two of the following questions, each within 1500 words; Draw diagrams wherever
necessary.
26) Describe photolithography and sol gel synthesis of nanoparticles.
27) Elaborate on the protein nanoarrays and nanoprotein mediated drug delivery.
28) What are Embryonic Stem Cells (ESCs)? Describe how human ESCs are derived?
What are the characteristics of ESCs, and draw the diagrams.
29) Describe tumour suppressor p53 gene and its role in cancer.
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