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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION - MEDICAL LAB. TECHNOLOGY
FIRST SEMESTER – NOVEMBER 2013
ML 1809 - MOLECULAR BIOLOGY
Date : 05/11/2013
Time : 1:00 - 4:00
Dept. No.
Answer ALL questions.
Max. : 100 Marks
Section – A
10 x 2 = 20 Marks
1. What are Oncogenes?
2. Draw the labeled structure of fluid mosaic model of plasma membrane.
3. Differentiate analytical sensitivity from analytical specificity.
4. What is mutagenesis?
5. List down the hereditary DNA repair disorders.
6. Comment on in situ hybridization.
7. Define centromere and telomere.
8. Expand NFSTC, CLIA, ICD and ABMS.
9. What are okazaki fragments?
10. Mention the role played by DNA gyrase and topoisomerase.
Answer any FOUR of the following
Section – B
4 x 10 = 40 Marks
11. Explain Laboratory facilities and clinical test formats in molecular diagnostic laboratory.
12. Give an account on translocation in cancers.
13. Describe the forensic identity testing by DNA analysis
14. Explain the Watson and Crick model and other forms of DNA. Illustrate.
15. Elaborate the types of genetic recombination.
16. Describe the characteristics of genetic code.
Answer any TWO of the following
Section – C
2 x 20 = 40 Marks
17. Draw the structure of eukaryotic cell and explain Cytoskeleton, Golgi complex and Nucleus.
18. Discuss the mechanism of bio-synthesis of protein.
19. Give an account on the morphology and functional elements of eukaryotic chromosomes
20. What is syndrome? Explain Prader willi syndrome and Sickle cell anaemia.
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